The Anti-NMDA Receptor Encephalitis Foundation Newsletter

Recently, autoantibodies against NMDA receptors (NMDARs) were identified as a major cause of autoimmune encephalitis. They cause abnormalities in brain function often associated with significant changes in patients’ brain dynamics.

 




F1000Prime Recommended Article: Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.

 




There is a very real possibility that what seems to be a psychiatric problem is caused by some physical illness. How common is this problem? Very…and not very.Most people will not have a medical disease masquerading as a neurobiological disorder (…

 




Electrographic Seizures in Patients with Acute Encephalitis From link.springer.com –…

 




Brief Communication N‐methyl‐D‐aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica** Russell C. Dale PhD Sarosh R. Irani MRCP Fabienne Brilot PhD Sekhar Pillai FRACP Richard Webster FRACP Deepak Gill FRACP Bethan Lang PhD Angela Vincent FRCPath First published: 20 July 2009 Cited by: 11 *Potential conflict of interest: A.V. and her department receive payments and royalties for antibody assays. *Pfizer had no role in study design, data collection, data analysis, data interpretation, or the writing of the manuscript. Abstract Encephalitis lethargica (EL) describes an encephalitis with psychiatric, sleep, and extrapyramidal movement disorders. Dyskinetic and Parkinsonian forms have been described. EL shares clinical features with the anti–N‐methyl‐D‐aspartate receptor (NMDAR‐Ab) encephalitis. We studied 20 sera from pediatric patients with contemporary EL. Ten sera (from 2 males and 8 females, aged 1.3–13 years) and 6/6 cerebrospinal fluid samples were positive for NMDAR‐Ab. NMDAR‐Ab–positive patients had dyskinesias, agitation, seizures, and insomnia, whereas Parkinsonism and somnolence dominated in the NMDAR‐Ab–negative children. We were unable to identify any tumors. The dyskinetic form of EL is an NMDAR‐Ab encephalitis and can affect very young children. Ann Neurol 2009;66:704–709 Citing Literature Number of times cited: 11 Elizabeth J. Slow and Anthony E. Lang, Oculogyric crises: A review of phenomenology, etiology, pathogenesis, and treatment, Movement Disorders, 32, 2, (193-202), (2017). Wiley Online Library Shannon J. Beasley and Judith M. Greer, Autoantibodies and their potential roles in diseases of the nervous system, Clinical and Experimental Neuroimmunology, 6, 4, (370-386), (2015). Wiley Online Library Frank Leypoldt, Thaís Armangue and Josep Dalmau, Autoimmune encephalopathies, Annals of the New York Academy of Sciences, 1338, 1, (94-114), (2014). Wiley Online Library Nese Sinmaz, Mazen Amatoury, Vera Merheb, Sudarshini Ramanathan, Russell C. Dale and Fabienne Brilot, Autoantibodies in movement and psychiatric disorders: updated concepts in detection methods, pathogenicity, and CNS entry, Annals of the New York Academy of Sciences, 1351, 1, (22-38), (2015). Wiley Online Library Jehan Suleiman and Russell C Dale, The recognition and treatment of autoimmune epilepsy in children, Developmental Medicine & Child Neurology, 57, 5, (431-440), (2014). Wiley Online Library Shekeeb S. Mohammad, Victor S.C. Fung, Padraic Grattan‐Smith, Deepak Gill, Sekhar Pillai, Sudarshini Ramanathan, Fabienne Brilot and Russell C. Dale, Movement disorders in children with anti‐NMDAR encephalitis and other autoimmune encephalopathies, Movement Disorders, 29, 12, (1539-1542), (2014). Wiley Online Library Sarosh R. Irani, Jeffrey M. Gelfand, Adam Al‐Diwani and Angela Vincent, Cell‐surface central nervous system autoantibodies: Clinical relevance and emerging paradigms, Annals of Neurology, 76, 2, (168-184), (2014). Wiley Online Library Jehan Suleiman, Sukhvir Wright, Deepak Gill, Fabienne Brilot, Patrick Waters, Ken Peacock, Peter Procopis, Anjan Nibber, Angela Vincent, Russell C. Dale and Bethan Lang, Autoantibodies to neuronal antigens in children with new‐onset seizures classified according to the revised ILAE organization of seizures and epilepsies, Epilepsia, 54, 12, (2091-2100), (2013). Wiley Online Library Edgar Meinl, Tobias Derfuss and Chris Linington, Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements, Clinical and Experimental Neuroimmunology, 1, 2, (47-60), (2010). Wiley Online Library Michael P. Malter, Christoph Helmstaedter, Horst Urbach, Angela Vincent and Christian G. Bien, Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis, Annals of Neurology, 67, 4, (470-478), (2009). Wiley Online Library Valentina Damato, Bettina Balint, Anne‐Kathrin Kienzler and Sarosh R. Irani, The clinical features, underlying immunology, and treatment of autoantibody‐mediated movement disorders, Movement Disorders, , (2018). Wiley Online Library Volume66, Issue5 November 2009 Pages 704-709

 




A bone-marrow transplant treated a patient’s leukemia — and his delusions, too. Some doctors think they know why….

 




Autoimmune diseases of the nervous system (ADNS) consist of a group of severely disabling disorders characterized by abnormal immune attack against protein components of the nervous system. This type of attack behavior may occur in the central or peripheral nervous system, and in the neuromuscular…

 




There has been a recent surge in studies reporting findings from electroencephalographic data in patients with anti-NMDA receptor encephalitis (ANMDARE). Most studies to-date have described …Read More…

 




Dr Sarosh Irani and Dr Rachel Kneen talk about the future of encephalitis and what is being done to improve not only the diagnosis but the treatment process …

 




The K-J. Zülch Prize of the Gertrud Reemtsma Foundation has been awarded for outstanding achievements in basic neurological research every year since 1990.

 




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