The Anti-NMDA Receptor Encephalitis Foundation Newsletter

In late 1916, while the world was entrenched in the Great War, two physicians on opposing sides of the conflict started to encounter patients who presented with bizarre neurological signs. Most notably, the patients experienced profound lethargy, and would sleep for abnormally long periods of time.

 




A newly recognized category of epilepsy caused by or associated with antibodies.

 




Front Neurol. 2018 Oct 10;9:841. doi: 10.3389/fneur.2018.00841. eCollection 2018.Review…

 




Several studies have reported common presentations accompanying immunoglobulin G (IgG) antibodies targeting the neuronal cell adhesion protein IgLON5.1–3 Complex sleep and movement disorders, gait imbalance, and bulbar symptoms are prominent features.

 




The Anti-NMDA Receptor Encephalitis Foundation, Inc. is pleased to announce its collaboration with the Hashimoto’s Encephalopothy SREAT Alliance (HESA), in the organization of a medical …Read More…

 




Neurol Clin. 2018 Nov;36(4):705-724. doi: 10.1016/j.ncl.2018.07.001. Epub 2018 Sep 20.Review…

 




A year ago, Ariana Pila was in a comatose state, after being struck down by an ultra-rare autoimmune disease. Now she is preparing to walk the Great Wall of China.

 




Among the one-third of adults with epilepsy of unknown etiology, an autoimmune cause appears to be the culprit in at least 20%. This new scoring system may help identify them.

 




Neurological Sciences October 2018, Volume 39, Issue 10, pp 1815–1817 | Cite as Lyme borreliosis as a trigger for NMDA receptor encephalitis? Authors Authors and affiliations Hector R. Martinez Leticia A. Olguin-Ramirez Carlos R. Camara-Lemarroy Letter to the Editor First Online: 14 July 2018 88 Downloads Dear Editor: NMDA receptor (NMDAR) encephalitis was initially described by Dalmau et al. [1] and is associated to a constellation of symptoms such as psychosis, memory deficits, seizures, abnormal movements, and autonomic dysfunction. In many patients, these autoantibodies occur in the setting of underlying tumor (teratomas), but in the remainder of patients, the immunopathogenesis remains unclear. Recent reports suggest that viral infections may trigger NMDAR [2], leading to speculation that mechanisms such as molecular mimicry and/or bystander activation may play a role. A 32-year-old male was referred from a psychiatric hospital where he was hospitalized due to a gradual onset of behavioral changes, depression, memory loss, dysarthria, auditory hallucinations, irritability and aggressiveness. After 1 month of olanzapine, risperidone, clonazepam, valproate and biperiden treatment with no response, he was transferred to our care for neurologic evaluation. The past history was… This is a preview of subscription content, log in to check access. Notes Compliance with ethical standards Conflict of interest The authors declare that they have no conflict of interest. Ethical approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent Informed consent was obtained from all individual participants included in the study. References 1. Guasp M, Dalmau J (2017) Encephalitis associated with antibodies against the NMDA receptor. Med Clin (Barc) 151:71–79 CrossRefGoogle Scholar 2. Prüss H (2017) Postviral autoimmune encephalitis: manifestations in children and adults. Curr Opin Neurol 30:327–333 CrossRefPubMedGoogle Scholar 3. Gable MS, Gavali S, Radner A et al (2009) Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis 28:1421–1429 CrossRefPubMedPubMedCentralGoogle Scholar 4. Hansen K, Crone C, Kristoferitsch W (2013) Lyme neuroborreliosis. Handb Clin Neurol 115:559–575 CrossRefPubMedGoogle Scholar 5. Gordillo G, Torres J, Solorzano F, Cedillo-Rivera R, Tapia-Conyer R, Muñoz O (1999) Serologic evidences suggesting the presence of Borrelia burgdorferi infection in Mexico. Arch Med Res 30:64–68 CrossRefPubMedGoogle Scholar Copyright information © Springer-Verlag Italia S.r.l., part of Springer Nature 2018 Authors and Affiliations Hector R. Martinez12Email authorView author’s OrcID profile Leticia A. Olguin-Ramirez1 Carlos R. Camara-Lemarroy123 1.Instituto de Neurologia y Neurocirugía, Tecnologico de MonterreyHospital Zambrano HellionSan Pedro Garza GarciaMexico 2.Servicio de NeurologíaHospital Universitario Universidad Autónoma de Nuevo León (UANL)MonterreyMexico 3.Department of Clinical Neurosciences, Cumming School of MedicineUniversity of CalgaryCalgaryCanada

 




JRSM Open. 2018 Sep 3;9(9):2054270418793021. doi: 10.1177/2054270418793021. eCollection 2018 Sep.

 




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