Immunotherapy with immune-checkpoint inhibitors (ICIs) is a new pillar in the treatment of cancer but can a have range of immune-related adverse effects, including some rare neurological toxicities that constitute paraneoplastic neurological syndromes (PNSs).
In their paper, Recken and colleagues, review the different autoantibodies, related clinical presentations and cancer associations and detection methods for autoantibodies. The review was comprehensive and nicely described most of the established antibodies.
The Netflix drama ‘Brain on Fire is the story of a young woman in the U.S. who suddenly develops severe psychiatric symptoms. Some clever detective work reveals that she has a rare and mysterious condition causing brain inflammation.
The presence of autoantibodies against neuronal cell surface or synaptic proteins and their relationship to autoimmune encephalitis have recently been characterized. These autoantibodies have been also reported in other pathologic conditions; however, their role during sepsis is not known.
Chinese is perhaps the only hieroglyphic language still in use. The oldest Chinese
characters are found in oracle inscriptions on bones or tortoise shells of the Shang
Dynasty (16th–11th century BC), expressing concepts through hieroglyphic and ideographic
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis was first reported in 2005 in four patients with ovarian teratomas; there have been many further cases reported since the antigen for the NMDAR antibody was confirmed in 2007.
Encephalitis with anti-NMDAR antibodies (NMDAR-E) is a severe autoimmune neurological disorder, defined by a clinical presentation of encephalitis and the presence of IgG targeting the GluN1 subunit o…
Antibodies against N-methyl D-aspartate receptor (NMDAR) and other neuronal cell surface targets are recognised associations of immunotherapy-responsive autoimmune encephalitis. Initially, patients present with symptoms of behavioural change and psychosis, often subsequently developing seizures…