The Anti-NMDA Receptor Encephalitis Foundation Newsletter

The 20th century marked the rise of status epilepticus.Previously thought to be a relatively obscure clinical phenomenon, by the beginning of the century, stat…

 




Ann Clin Transl Neurol. 2019 Apr 11;6(5):945-953. doi: 10.1002/acn3.740. eCollection 2019 May.

 




Front Neurol. 2019 May 14;10:472. doi: 10.3389/fneur.2019.00472. eCollection 2019.

 




What if one day your child suddenly began exhibiting mysterious symptoms like something out of a horror movie? Timothy Caulfield, Canada’s official pseudosci…

 




PDF Editorial commentary Link between HLA alleles and anti-NMDAR encephalitis Noriko Isobe Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan Correspondence to Dr Noriko Isobe, Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; kuroki{at}neuro.med.kyushu-u.ac.jp Statistics from Altmetric.com HLA-DRB1*16:02 is a disease susceptibility allele for anti-NMDAR encephalitis in the Chinese Han population Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is one of the major types of antibody-mediated autoimmune encephalitis. It was originally reported to be highly prevalent in young women with ovarian teratoma, but later studies found that the cases were not limited to young women with tumours; it was observed in both genders of any age, irrespective of tumour positivity.1 Clinical manifestations include neuropsychiatric syndrome with movement disorders, seizures and autonomic dysfunction. Recently, several studies have reported human leucocyte antigen (HLA) associations with antibody-mediated encephalitis, including anti-NMDAR encephalitis and anti-leucine-rich glioma-inactivated1 (LGI1) encephalitis. While HLA-DRB1*07:01 or its extended … View Full Text Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. Copyright information: © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Linked Articles Neurogenetics Yaqing Shu Wei Qiu Junfeng Zheng Xiaobo Sun Junping Yin Xiaoli Yang Xiaoyang Yue Chen Chen Zhihui Deng Shasha Li Yu Yang Fuhua Peng Zhengqi Lu Xueqiang Hu Frank Petersen Xinhua Yu Journal of Neurology, Neurosurgery & Psychiatry 2019; 90 652-658 Published Online First: 13 Jan 2019. doi: 10.1136/jnnp-2018-319714 Read the full text or download the PDF: Subscribe Log in

 




Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is accepted as an autoimmune disorder of the central nervous system (CNS). NLR family pyrin domain containing 3 (NLRP3) inflammasome, a potent innate inflammatory mediator, can activate IL-1β and induce the migration of T helper cell into CNS.

 




Medicine (Baltimore). 2019 May;98(20):e15706. doi: 10.1097/MD.0000000000015706.Case Reports…

 




The notion of immunological pathways playing a role in the etiology of a subset of psychotic disorders has received increased interest in the last decades. One of the findings that has spiked interest herein, is an apparent link between autoimmune diseases …

 




Tim Caulfield investigates a rare disease, laying bare its unnerving nexus of spirituality, neurology and psychiatry.

 




Psychiatry Clin Neurosci. 2019 May 22. doi: 10.1111/pcn.12867.[Epub ahead of print]…

 




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