What happens when you have a creative social worker, with an interest in the altered brain, working out of a large city hospital and who is also a producer of podcasts? Our brains become lit with excitement, as today she has published her podcast, titled My Brain is on Fire. The Anti-NMDA Receptor Encephalitis Foundation in collaboration with Laura Vander Steen the producer of the i lobe you podcast is excited to present the six-episode podcaston the “mother of all maladies”, anti-NMDA receptor encephalitis. The podcast combines interviews with survivors, caregivers and features neurologist and Partner Physician, Dr. C. Uy, with storytelling, sound effects and music, to present anti-NMDA receptor encephalitis, in all its facets, from its presumed past of demonic possession to its discovery in the present. You can either binge listen to all the episodes or space them out. For those that you are currently going through this illness or are in early recovery, we recommend listening in reverse order, as the first 3 episodes have sound effects and content that may be triggering. Listen here, now: https://www.ilobeyou.ca/ and don’t forget to rate, review and share widely, to help raise awareness but to also be eligible for a gift draw from i lobeyou. Meet the lovely host with the silky, smooth voice, Laura Vander Steen, here: https://www.ilobeyou.ca/about
|
A boy from Des Moines with a rare immune system condition is this week’s University of Iowa Stead Family Children’s Hospital Kid Captain for the school’s matchup against Middle Tennessee State on Saturday.
|
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
|
Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms.Here, we describe a 69-year-old patien…
|
Encephalitis is a condition of inflammation of the brain parenchyma, occurs as a result
of infectious or autoimmune causes, and can lead to encephalopathy, seizures, focal
neurological deficits, neurological disability, and death.
|
|
Abstract Objectives To evaluate the long‐term cognitive or neuropsychiatric outcomes and potential risk factors associated with prolonged cognitive deficits or neuropsychiatric symptoms in patients…
|
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
|
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, is caused by the production of autoantibodies against NMDA receptor. Anti-NMDAR encephalitis patients present with various non-specific symptoms, such as abnormal psychiatric or…
|
Researchers from North Carolina State University have found that dogs can suffer from the same type of autoimmune encephalitis that people do. The finding could lead to better screening methods for diagnosis and possibly …
|
1. Venkatesan A, Tunkel AR, Bloch KC et al (2013) Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis 57:1114–1128. https://doi.org/10.1093/cid/cit458 CrossRefPubMedPubMedCentralGoogle Scholar 2. Venkatesan A, Michael BD, Probasco JC et al (2019) Acute encephalitis in immunocompetent adults. Lancet 393:702–716. https://doi.org/10.1016/S0140-6736(18)32526-1 CrossRefPubMedGoogle Scholar 3. Dalmau J, Graus F (2018) Antibody-mediated encephalitis. N Engl J Med 378:840–851. https://doi.org/10.1056/NEJMra1708712 CrossRefPubMedPubMedCentralGoogle Scholar 4. Jeannin-Mayer S, André-Obadia N, Rosenberg S et al (2019) EEG analysis in anti-NMDA receptor encephalitis: description of typical patterns. Clin Neurophysiol 130:289–296. https://doi.org/10.1016/j.clinph.2018.10.017 CrossRefPubMedGoogle Scholar 5. Probasco JC, Solnes L, Nalluri A et al (2017) Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis. Neurol Neuroimmunol Neuroinflamm 11:e352. https://doi.org/10.1212/NXI.0000000000000352 CrossRefGoogle Scholar 6. Graus F, Titulaer MJ, Balu R et al (2016) A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 15:391–404. https://doi.org/10.1016/S1474-4422(15)00401-9 CrossRefPubMedPubMedCentralGoogle Scholar 7. Titulaer MJ, McCracken L, Gabilondo I et al (2013) Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 12:157–165. https://doi.org/10.1016/S1474-4422(12)70310-1 CrossRefPubMedPubMedCentralGoogle Scholar 8. Viaccoz A, Desestret V, Ducray F et al (2014) Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis. Neurology 82:556–563. https://doi.org/10.1212/WNL.0000000000000126 CrossRefPubMedGoogle Scholar 9. Armangue T, Spatola M, Vlagea A et al (2018) Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis. Lancet Neurol 17:760–772. https://doi.org/10.1016/S1474-4422(18)30244-8 CrossRefPubMedPubMedCentralGoogle Scholar 10. Sonneville R, Demeret S, Klein I et al (2008) Acute disseminated encephalomyelitis in the intensive care unit: clinical features and outcome of 20 adults. Intensive Care Med 34:528–532. https://doi.org/10.1007/s00134-007-0926-2 CrossRefPubMedGoogle Scholar 11. de Montmollin E, Demeret S, Brulé N et al (2017) Anti-N-methyl-d-aspartate receptor encephalitis in adult patients requiring intensive care. Am J Respir Crit Care Med 195:491–499. https://doi.org/10.1164/rccm.201603-0507OC CrossRefPubMedGoogle Scholar 12. Lancaster E (2016) The diagnosis and treatment of autoimmune encephalitis. J Clin Neurol 12:1–13. https://doi.org/10.3988/jcn.2016.12.1.1 CrossRefPubMedGoogle Scholar 13. Scheibe F, Prüss H, Mengel AM et al (2017) Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis. Neurology 88:366–370. https://doi.org/10.1212/WNL.0000000000003536 CrossRefPubMedGoogle Scholar 14. Cohen J, Sotoca J, Gandhi S et al (2019) Autoimmune encephalitis: a costly condition. Neurology. https://doi.org/10.1212/WNL.0000000000006990.10.1212/WNL.0000000000006990 CrossRefPubMedGoogle Scholar 15. Sonneville R, Mariotte E, Neuville M et al (2016) Early-onset status epilepticus in patients with acute encephalitis. Medicine 95:e4092. https://doi.org/10.1097/MD.0000000000004092 CrossRefPubMedPubMedCentralGoogle Scholar 16. Geis C, Planagumà J, Carreño M et al (2019) Autoimmune seizures and epilepsy. J Clin Investig 129:926–940. https://doi.org/10.1172/JCI125178 CrossRefPubMedGoogle Scholar 17. de Bruijn MAAM, van Sonderen A, van Coevorden-Hameete MH et al (2019) Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABABR encephalitis. Neurology 92:e2185–e2196. https://doi.org/10.1212/WNL.0000000000007475 CrossRefPubMedPubMedCentralGoogle Scholar 18. Lejuste F, Thomas L, Picard G et al (2016) Neuroleptic intolerance in patients with anti-NMDAR encephalitis. Neurol Neuroimmunol Neuroinflamm 3:e280. https://doi.org/10.1212/NXI.0000000000000280 CrossRefPubMedPubMedCentralGoogle Scholar 19. Schubert J, Brämer D, Huttner HB et al (2019) Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment. Neurol Neuroimmunol Neuroinflamm 6:e514. https://doi.org/10.1212/NXI.0000000000000514 CrossRefPubMedGoogle Scholar 20. Balu R, McCracken L, Lancaster E et al (2019) A score that predicts 1 year functional status in patients with anti-NMDA receptor encephalitis. Neurology 92:e244–e252. https://doi.org/10.1212/WNL.0000000000006783 CrossRefPubMedPubMedCentralGoogle Scholar 21. Mittal MK, Rabinstein AA, Hocker SE et al (2016) Autoimmune encephalitis in the ICU: analysis of phenotypes, serologic findings, and outcomes. Neurocrit Care 24:240–250. https://doi.org/10.1007/s12028-015-0196-8 CrossRefPubMedGoogle Scholar 22. Wells E, Hacohen Y, Waldman A et al (2018) Neuroimmune disorders of the central nervous system in children in the molecular era. Nat Rev Neurol 14:433–445. https://doi.org/10.1038/s41582-018-0024-9 CrossRefPubMedGoogle Scholar
|
|
